2bze

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[[Image:2bze.gif|left|200px]]
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{{Seed}}
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[[Image:2bze.png|left|200px]]
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{{STRUCTURE_2bze| PDB=2bze | SCENE= }}
{{STRUCTURE_2bze| PDB=2bze | SCENE= }}
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'''NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.'''
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===NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.===
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==Overview==
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The yeast Paf1 complex consists of Paf1, Rtf1, Cdc73, Ctr9, and Leo1 and regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. We provide structural insight into the Paf1 complex with the NMR structure of the conserved and functionally important Plus3 domain of human Rtf1. A predominantly beta-stranded subdomain displays structural similarity to Dicer/Argonaute PAZ domains and to Tudor domains. We further demonstrate that the highly basic Rtf1 Plus3 domain can interact in vitro with single-stranded DNA via residues on the rim of the beta sheet, reminiscent of siRNA binding by PAZ domains, but did not detect binding to double-stranded DNA or RNA. We discuss the potential role of Rtf1 Plus3 ssDNA binding during transcription elongation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18184592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18184592}}
==About this Structure==
==About this Structure==
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2BZE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZE OCA].
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2BZE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZE OCA].
==Reference==
==Reference==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:03:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:22:05 2008''

Revision as of 21:22, 27 July 2008

Image:2bze.png

Template:STRUCTURE 2bze

NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.

Template:ABSTRACT PUBMED 18184592

About this Structure

2BZE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and DNA binding of the human Rtf1 Plus3 domain., de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, Folkers GE, Structure. 2008 Jan;16(1):149-59. PMID:18184592

Page seeded by OCA on Mon Jul 28 00:22:05 2008

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