6jxw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex of SUMO2 bound SLS4 from ICP0.== | |
| - | + | <StructureSection load='6jxw' size='340' side='right'caption='[[6jxw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jxw]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JXW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxw OCA], [http://pdbe.org/6jxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxw RCSB], [http://www.ebi.ac.uk/pdbsum/6jxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxw ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Das, R]] | ||
| + | [[Category: Hembram, D S.S]] | ||
| + | [[Category: Negi, H]] | ||
| + | [[Category: Shet, D]] | ||
| + | [[Category: Protein binding-peptide complex]] | ||
| + | [[Category: Sumoylation]] | ||
Revision as of 07:59, 5 February 2020
Complex of SUMO2 bound SLS4 from ICP0.
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