2jsd

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[[Image:2jsd.jpg|left|200px]]
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{{STRUCTURE_2jsd| PDB=2jsd | SCENE= }}
{{STRUCTURE_2jsd| PDB=2jsd | SCENE= }}
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'''Solution structure of MMP20 complexed with NNGH'''
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===Solution structure of MMP20 complexed with NNGH===
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==Overview==
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The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.
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{{ABSTRACT_PUBMED_17869250}}
==About this Structure==
==About this Structure==
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2JSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA].
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2JSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 16:24:31 2008''

Revision as of 13:24, 5 July 2008

Image:2jsd.png

Template:STRUCTURE 2jsd

Solution structure of MMP20 complexed with NNGH

Template:ABSTRACT PUBMED 17869250

About this Structure

2JSD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase., Arendt Y, Banci L, Bertini I, Cantini F, Cozzi R, Del Conte R, Gonnelli L, FEBS Lett. 2007 Oct 2;581(24):4723-6. Epub 2007 Sep 6. PMID:17869250

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