6rj8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the alpha-beta hydrolase CorS from Tabernathe iboga== | |
| + | <StructureSection load='6rj8' size='340' side='right'caption='[[6rj8]], [[Resolution|resolution]] 1.42Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rj8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJ8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-hydroxyisoflavanone_dehydratase 2-hydroxyisoflavanone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.105 4.2.1.105] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rj8 OCA], [http://pdbe.org/6rj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rj8 RCSB], [http://www.ebi.ac.uk/pdbsum/6rj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rj8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distinct scaffolds. Mutational analysis reveals how these highly similar enzymes control regio- and stereo-selectivity. | ||
| - | + | Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.,Caputi L, Franke J, Bussey K, Farrow SC, Vieira IJC, Stevenson CEM, Lawson DM, O'Connor SE Nat Chem Biol. 2020 Feb 17. pii: 10.1038/s41589-019-0460-x. doi:, 10.1038/s41589-019-0460-x. PMID:32066966<ref>PMID:32066966</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6rj8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 2-hydroxyisoflavanone dehydratase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bussey, K]] | ||
| + | [[Category: Caputi, L]] | ||
| + | [[Category: Connor, S E.O]] | ||
| + | [[Category: Farrow, S C]] | ||
| + | [[Category: Kamileen, M O]] | ||
| + | [[Category: Lawson, D M]] | ||
| + | [[Category: Mundy, J]] | ||
| + | [[Category: Stevenson, C E.M]] | ||
| + | [[Category: Alkaloid]] | ||
| + | [[Category: Alpha/beta hydrolase fold]] | ||
| + | [[Category: Biosynthesis]] | ||
| + | [[Category: Coronaridine]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Iboga]] | ||
| + | [[Category: Natural product]] | ||
Revision as of 06:47, 4 March 2020
Structure of the alpha-beta hydrolase CorS from Tabernathe iboga
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