CD4

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HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
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==3D structures of CD4==
 +
[[CD4 3D structures]]
</StructureSection>
</StructureSection>
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*CD4 domains
*CD4 domains
-
**[[1cid]] – rCD4 D3 and D4 domains - rat<BR />
+
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1-D2 domains - human<BR />
-
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR />
+
**[[1cdu]], [[1cdy]] – hCD4 D1-D2 domains (mutant)<BR />
-
**[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR />
+
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1-D4 domains <BR />
-
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR />
+
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
 +
**[[1cid]] – rCD4 D3-D4 domains - rat<BR />
*CD4 binary complex
*CD4 binary complex
-
**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
 
**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
-
**[[3o2d]], [[4q9i]] – hCD4 D1 and D2 domains + antibody <BR />
+
**[[3o2d]], [[4q9i]] – hCD4 D1-D2 domains + antibody <BR />
-
**[[5cay]] – hCD4 D1 and D2 domains + gp120 <BR />
+
**[[5cay]] – hCD4 D1-D2 domains + gp120 <BR />
 +
**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
*CD4 higher complexes
*CD4 higher complexes
-
**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
+
**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1-D2 domains + antibody + gp120<BR />
-
**[[3j70]], [[5u1f]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41<BR />
+
**[[3j70]], [[5u1f]] – hCD4 D1-D2 domains + antibody + gp120 + gp41<BR />
-
**[[5thr]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
+
**[[5thr]] – hCD4 D1-D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
-
**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
+
**[[2qad]], [[3lqa]], [[6edu]], [[6cm3]], [[5vn3]] – hCD4 D1-D2 domains + antibody + gp160<BR />
-
**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />
+
**[[1jl4]] – hCD4 D1-D2 domains + class II MHC + ovotransferin peptide<BR />
-
**[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR />
+
**[[3s4s]] – hCD4 D1-D2 domains + class II MHC + haemaglutinin peptide<BR />
-
**[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR />
+
**[[3s5l]] – hCD4 D1-D2 domains + class II MHC + HA peptide<BR />
-
**[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR />
+
**[[3t0e]] – hCD4 D1-D2 domains + class II MHC + TCR<BR />
 +
**[[6meo]], [[6met]] – hCD4 D1-D3 domains + CCR5 + gp120<BR />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 08:56, 1 May 2019

Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry 2nxy)

Drag the structure with the mouse to rotate

3D structures of CD4

Updated on 01-May-2019

References

  1. ↑ Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF, Barclay AN. Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains. Science. 1993 May 14;260(5110):979-83. PMID:8493535
  2. ↑ Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature. 2007 Feb 15;445(7129):732-7. PMID:17301785 doi:http://dx.doi.org/10.1038/nature05580

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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