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1nm4

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{{STRUCTURE_1nm4| PDB=1nm4 | SCENE= }}
{{STRUCTURE_1nm4| PDB=1nm4 | SCENE= }}
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'''Solution structure of Cu(I)-CopC from Pseudomonas syringae'''
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===Solution structure of Cu(I)-CopC from Pseudomonas syringae===
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==Overview==
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The protein CopC from Pseudomonas syringae has been found capable of binding copper(I) and copper(II) at two different sites, occupied either one at a time or simultaneously. The protein, consisting of 102 amino acids, is known to bind copper(II) in a position that is now found consistent with a coordination arrangement including His-1, Glu-27, Asp-89, and His-91. A full solution structure analysis is reported here for Cu(I)-CopC. The copper(I) site is constituted by His-48 and three of the four Met residues (40, 43, 46, 51), which are clustered in a Met-rich region. Both copper binding sites have been characterized through extended x-ray absorption fine structure studies. They represent novel coordination environments for copper in proteins. The two sites are approximately 30 A far apart and have little affinity for the ion in the other oxidation state. Oxidation of Cu(I)-CopC or reduction of Cu(II)-CopC causes migration of copper from one site to the other. This behavior is observed both in NMR and EXAFS studies and indicates that CopC can exchange copper between two sites activated by a redox switch. CopC resides in the periplasm of Gram-negative bacteria where there is a multicopper oxidase, CopA, which may modulate the redox state of copper. CopC and CopA are coded in the same operon, responsible for copper resistance. These peculiar and novel properties of CopC are discussed with respect to their relevance for copper homeostasis.
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{{ABSTRACT_PUBMED_12651950}}
==About this Structure==
==About this Structure==
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1NM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM4 OCA].
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1NM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM4 OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:00:24 2008''

Revision as of 07:00, 28 July 2008

Image:1nm4.png

Template:STRUCTURE 1nm4

Solution structure of Cu(I)-CopC from Pseudomonas syringae

Template:ABSTRACT PUBMED 12651950

About this Structure

1NM4 is a Single protein structure of sequence from Pseudomonas syringae. Full experimental information is available from OCA.

Reference

A redox switch in CopC: an intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites., Arnesano F, Banci L, Bertini I, Mangani S, Thompsett AR, Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3814-9. Epub 2003 Mar 21. PMID:12651950

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