5zi8

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Current revision (08:56, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5zi8' size='340' side='right'caption='[[5zi8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5zi8' size='340' side='right'caption='[[5zi8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZI8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZI8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3488 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zi8 OCA], [http://pdbe.org/5zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5zi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zi8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zi8 OCA], [https://pdbe.org/5zi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zi8 RCSB], [https://www.ebi.ac.uk/pdbsum/5zi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zi8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDDTR_MYCTU CDDTR_MYCTU] May have transcription regulation and metal-detoxifying functions through which it may enhance intracellular survival of mycobacteria. Binds to its own promoter region and to the Rv1999c promoter region. It displays strong affinity for cadmium ions, but can also bind zinc, manganese and nickel. Expression increases the intracellular survival of recombinant M. smegmatis in murine macrophage cell line and increases its tolerance to cadmium ions.<ref>PMID:30266832</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zi8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zi8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Arora, A]]
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[[Category: Arora A]]
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[[Category: Biswal, B K]]
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[[Category: Biswal BK]]
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[[Category: Meera, K]]
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[[Category: Meera K]]
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[[Category: Pal, R K]]
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[[Category: Pal RK]]
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[[Category: Dna binding protein]]
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Current revision

Crystal structure of the PadR-family transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv in complex with cadmium ion

PDB ID 5zi8

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