6dda

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Current revision (09:55, 25 December 2024) (edit) (undo)
 
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<StructureSection load='6dda' size='340' side='right'caption='[[6dda]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6dda' size='340' side='right'caption='[[6dda]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dda]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DDA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=G7J:5-hydroxy-1,2-dihydro-6H-indol-6-one'>G7J</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=G7J:5-hydroxy-1,2-dihydro-6H-indol-6-one'>G7J</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR4A2, NOT, NURR1, TINUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dda OCA], [https://pdbe.org/6dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dda RCSB], [https://www.ebi.ac.uk/pdbsum/6dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dda ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dda OCA], [http://pdbe.org/6dda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dda RCSB], [http://www.ebi.ac.uk/pdbsum/6dda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dda ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN]] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
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[https://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bhattacharya, P]]
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[[Category: Bhattacharya P]]
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[[Category: Boxue, T]]
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[[Category: Boxue T]]
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[[Category: Bruning, J M]]
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[[Category: Bruning JM]]
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[[Category: England, P M]]
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[[Category: England PM]]
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[[Category: Fletterick, R J]]
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[[Category: Fletterick RJ]]
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[[Category: Guo, S]]
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[[Category: Guo S]]
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[[Category: Holton, J M]]
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[[Category: Holton JM]]
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[[Category: Jacobson, M P]]
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[[Category: Jacobson MP]]
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[[Category: Liu, H]]
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[[Category: Liu H]]
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[[Category: Otrabella, F]]
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[[Category: Otrabella F]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Cysteine adduct]]
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[[Category: Dihydroxyindole]]
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[[Category: Dopamine]]
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[[Category: Nurr1]]
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[[Category: Transcription]]
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Current revision

Nurr1 Covalently Modified by a Dopamine Metabolite

PDB ID 6dda

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