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4raf

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<StructureSection load='4raf' size='340' side='right'caption='[[4raf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4raf' size='340' side='right'caption='[[4raf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4raf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4raf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ra2|4ra2]], [[4rag|4rag]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4raf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4raf OCA], [https://pdbe.org/4raf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4raf RCSB], [https://www.ebi.ac.uk/pdbsum/4raf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4raf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPM1A, PPPM1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4raf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4raf OCA], [http://pdbe.org/4raf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4raf RCSB], [http://www.ebi.ac.uk/pdbsum/4raf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4raf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>
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[https://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Protein phosphatase|Protein phosphatase]]
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Liu HD]]
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[[Category: Liu, H D]]
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[[Category: Meng FG]]
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[[Category: Meng, F G]]
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[[Category: Pan C]]
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[[Category: Pan, C]]
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[[Category: Sun JP]]
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[[Category: Sun, J P]]
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[[Category: Tang JY]]
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[[Category: Tang, J Y]]
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[[Category: Wang HA]]
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[[Category: Wang, H A]]
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[[Category: Wang WB]]
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[[Category: Wang, W B]]
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[[Category: Xiao P]]
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[[Category: Xiao, P]]
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[[Category: Xu YF]]
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[[Category: Xu, Y F]]
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[[Category: Yu X]]
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[[Category: Yu, X]]
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[[Category: Metal binding protein]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine phosphatase]]
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Revision as of 06:47, 2 March 2023

Crystal structure of PP2Ca-D38A

PDB ID 4raf

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