4rnq

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<StructureSection load='4rnq' size='340' side='right'caption='[[4rnq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='4rnq' size='340' side='right'caption='[[4rnq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rnq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RNQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RNQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=A4S:(2E,6E)-3,7-DIMETHYL-8-(PHENYLAMINO)OCTA-2,6-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>A4S</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=A4S:(2E,6E)-3,7-DIMETHYL-8-(PHENYLAMINO)OCTA-2,6-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>A4S</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EAS3, EAS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4097 American tobacco])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnq OCA], [https://pdbe.org/4rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rnq RCSB], [https://www.ebi.ac.uk/pdbsum/4rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnq ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-epiaristolochene_synthase 5-epiaristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.61 4.2.3.61] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnq OCA], [http://pdbe.org/4rnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rnq RCSB], [http://www.ebi.ac.uk/pdbsum/4rnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnq ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
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[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5-epiaristolochene synthase]]
 
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[[Category: American tobacco]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chappell, J]]
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[[Category: Nicotiana tabacum]]
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[[Category: Crenshaw, C M]]
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[[Category: Chappell J]]
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[[Category: Koo, H J]]
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[[Category: Crenshaw CM]]
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[[Category: Noel, J P]]
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[[Category: Koo HJ]]
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[[Category: Spielmann, H P]]
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[[Category: Noel JP]]
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[[Category: Starks, C]]
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[[Category: Spielmann HP]]
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[[Category: 5-epi-aristolochene synthase]]
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[[Category: Starks C]]
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[[Category: Geraniline]]
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[[Category: Lyase]]
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[[Category: Tea]]
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[[Category: Terpene synthase]]
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Revision as of 08:21, 8 March 2023

Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline

PDB ID 4rnq

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