1pfj

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[[Image:1pfj.gif|left|200px]]
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[[Image:1pfj.png|left|200px]]
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{{STRUCTURE_1pfj| PDB=1pfj | SCENE= }}
{{STRUCTURE_1pfj| PDB=1pfj | SCENE= }}
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'''Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit'''
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===Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit===
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==Overview==
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The human general transcription factor TFIIH is involved in both transcription and DNA repair. We have identified a structural domain in the core subunit of TFIIH, p62, which is absolutely required for DNA repair activity through the nucleotide excision repair pathway. Using coimmunoprecipitation experiments, we showed that this activity involves the interaction between the N-terminal domain of p62 and the 3' endonuclease XPG, a major component of the nucleotide excision repair machinery. Furthermore, we reconstituted a functional TFIIH particle with a mutant of p62 lacking the N-terminal domain, showing that this domain is not required for assembly of the TFIIH complex and basal transcription. We solved its three-dimensional structure and found an unpredicted pleckstrin homology and phosphotyrosine binding (PH/PTB) domain, uncovering a new class of activity for this fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 15195146 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15195146}}
==About this Structure==
==About this Structure==
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1PFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFJ OCA].
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1PFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFJ OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:09:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:31:34 2008''

Revision as of 04:31, 29 July 2008

Image:1pfj.png

Template:STRUCTURE 1pfj

Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit

Template:ABSTRACT PUBMED 15195146

About this Structure

1PFJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

TFIIH contains a PH domain involved in DNA nucleotide excision repair., Gervais V, Lamour V, Jawhari A, Frindel F, Wasielewski E, Dubaele S, Egly JM, Thierry JC, Kieffer B, Poterszman A, Nat Struct Mol Biol. 2004 Jul;11(7):616-22. Epub 2004 Jun 13. PMID:15195146

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