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4ruh
From Proteopedia
(Difference between revisions)
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<StructureSection load='4ruh' size='340' side='right'caption='[[4ruh]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='4ruh' size='340' side='right'caption='[[4ruh]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ruh]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ruh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruh OCA], [https://pdbe.org/4ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ruh RCSB], [https://www.ebi.ac.uk/pdbsum/4ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ruh ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CNDP2_HUMAN CNDP2_HUMAN] Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.<ref>PMID:17121880</ref> <ref>PMID:19346245</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kaushik | + | [[Category: Kaushik A]] |
| - | [[Category: Kumaran | + | [[Category: Kumaran S]] |
| - | [[Category: Singh | + | [[Category: Singh AK]] |
| - | [[Category: Singh | + | [[Category: Singh RP]] |
| - | [[Category: Pandya | + | [[Category: Pandya V]] |
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Revision as of 08:28, 8 March 2023
Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A
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Categories: Homo sapiens | Large Structures | Kaushik A | Kumaran S | Singh AK | Singh RP | Pandya V
