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4r9j

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Current revision (06:46, 2 March 2023) (edit) (undo)
 
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<StructureSection load='4r9j' size='340' side='right'caption='[[4r9j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4r9j' size='340' side='right'caption='[[4r9j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r9j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R9J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r9j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R9J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3LJ:2-AMINO-2-DEOXY-6-O-SULFO-ALPHA-D-GLUCOPYRANOSE'>3LJ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LJ:2-AMINO-2-DEOXY-6-O-SULFO-ALPHA-D-GLUCOPYRANOSE'>3LJ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j0g|2j0g]], [[2j0h|2j0h]], [[2j0y|2j0y]], [[2j3o|2j3o]], [[4r9t|4r9t]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9j OCA], [https://pdbe.org/4r9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r9j RCSB], [https://www.ebi.ac.uk/pdbsum/4r9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r9j ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FCN2, FCNL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9j OCA], [http://pdbe.org/4r9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r9j RCSB], [http://www.ebi.ac.uk/pdbsum/4r9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r9j ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FCN2_HUMAN FCN2_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.<ref>PMID:10679061</ref>
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[https://www.uniprot.org/uniprot/FCN2_HUMAN FCN2_HUMAN] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.<ref>PMID:10679061</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gaboriaud, C]]
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[[Category: Gaboriaud C]]
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[[Category: Lacroix, M]]
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[[Category: Lacroix M]]
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[[Category: Laffly, E]]
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[[Category: Laffly E]]
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[[Category: Martin, L]]
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[[Category: Martin L]]
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[[Category: Thielens, N]]
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[[Category: Thielens N]]
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[[Category: Vassal-Stermann, E]]
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[[Category: Vassal-Stermann E]]
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[[Category: Extracellular]]
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[[Category: Fibrinogen-like domain]]
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[[Category: Immunology]]
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[[Category: Innate immunity]]
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[[Category: Lectin]]
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[[Category: Lectin-like]]
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[[Category: Pattern recognition protein]]
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[[Category: Plasma]]
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[[Category: Sugar binding protein]]
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Current revision

L-ficolin complexed to glucosamine-6-sulfate

PDB ID 4r9j

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