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4rw3

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<StructureSection load='4rw3' size='340' side='right'caption='[[4rw3]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='4rw3' size='340' side='right'caption='[[4rw3]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brown_spider Brown spider]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RW3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Loxosceles_intermedia Loxosceles intermedia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RW3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPD:D-MYO-INOSITOL-1-PHOSPHATE'>IPD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SHV:HEPTANOIC+ACID'>SHV</scene>, <scene name='pdbligand=TDA:N-TRIDECANOIC+ACID'>TDA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPD:D-MYO-INOSITOL-1-PHOSPHATE'>IPD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SHV:HEPTANOIC+ACID'>SHV</scene>, <scene name='pdbligand=TDA:N-TRIDECANOIC+ACID'>TDA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rw5|4rw5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rw3 OCA], [https://pdbe.org/4rw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rw3 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rw3 OCA], [http://pdbe.org/4rw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rw3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A1HB2_LOXIN A1HB2_LOXIN]] Catalyzes the hydrolysis of sphingomyelin. May also acts on other phosphatidyl esters. Induces complement-dependent hemolysis, dermonecrosis, blood vessel permeability and platelet aggregation.<ref>PMID:9790962</ref>
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[https://www.uniprot.org/uniprot/A1HB2_LOXIN A1HB2_LOXIN] Catalyzes the hydrolysis of sphingomyelin. May also acts on other phosphatidyl esters. Induces complement-dependent hemolysis, dermonecrosis, blood vessel permeability and platelet aggregation.<ref>PMID:9790962</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brown spider]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phospholipase D]]
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[[Category: Loxosceles intermedia]]
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[[Category: Arni, R K]]
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[[Category: Arni RK]]
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[[Category: Chahine, J]]
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[[Category: Chahine J]]
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[[Category: Chaim, O M]]
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[[Category: Chaim OM]]
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[[Category: Chaves-Moreira, D]]
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[[Category: Chaves-Moreira D]]
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[[Category: Coronado, M A]]
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[[Category: Coronado MA]]
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[[Category: Murakami, M T]]
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[[Category: Murakami MT]]
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[[Category: Silva, L S.da]]
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[[Category: Ullah A]]
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[[Category: Ullah, A]]
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[[Category: Veiga SS]]
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[[Category: Veiga, S S]]
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[[Category: Vuitika L]]
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[[Category: Vuitika, L]]
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[[Category: Da Silva LS]]
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[[Category: Hydrolase]]
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[[Category: Tim-barrel fold]]
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Revision as of 08:30, 8 March 2023

Structural insights into substrate binding of brown spider venom class II phospholipases D

PDB ID 4rw3

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