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4rou

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<StructureSection load='4rou' size='340' side='right'caption='[[4rou]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='4rou' size='340' side='right'caption='[[4rou]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rou OCA], [http://pdbe.org/4rou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rou RCSB], [http://www.ebi.ac.uk/pdbsum/4rou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rou ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rou OCA], [https://pdbe.org/4rou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rou RCSB], [https://www.ebi.ac.uk/pdbsum/4rou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rou ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MRPP3_HUMAN MRPP3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MRRP3_HUMAN MRRP3_HUMAN]] Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.<ref>PMID:18984158</ref>
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[https://www.uniprot.org/uniprot/MRPP3_HUMAN MRPP3_HUMAN] Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).<ref>PMID:18984158</ref> <ref>PMID:25953853</ref> <ref>PMID:34715011</ref>
== References ==
== References ==
<references/>
<references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, F]]
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[[Category: Li F]]
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[[Category: Liu, X]]
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[[Category: Liu X]]
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[[Category: Shen, Y]]
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[[Category: Shen Y]]
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[[Category: Yang, X]]
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[[Category: Yang X]]
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[[Category: Hydrolase]]
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[[Category: Mitochondria]]
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Revision as of 08:22, 8 March 2023

Auto-inhibition Mechanism of Human Mitochondrial RNase P Protein Complex

PDB ID 4rou

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