1s6o

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{{STRUCTURE_1s6o| PDB=1s6o | SCENE= }}
{{STRUCTURE_1s6o| PDB=1s6o | SCENE= }}
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'''Solution structure and backbone dynamics of the apo-form of the second metal-binding domain of the Menkes protein ATP7A'''
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===Solution structure and backbone dynamics of the apo-form of the second metal-binding domain of the Menkes protein ATP7A===
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==Overview==
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The second domain of the human Menkes protein (MNK2), formed by 72 residues, has been expressed in Escherichia coli, and its structure has been determined by NMR in both the apo and copper-loaded forms. The structures, obtained with (13)C- and (15)N-labeled samples, are of high quality with backbone rmsd values of 0.51 and 0.41 A and CYANA target functions of 0.39 and 0.38 A(2), respectively. The loop involved in copper binding is part of a hydrophobic patch, which is maintained in both forms. Conformational mobility is observed in the apo form in the same loop. A comparison with metallochaperones and soluble domains of P-type ATPases allows us to relate the primary structure to the occurrence of structural rearrangements upon copper binding.
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{{ABSTRACT_PUBMED_15035611}}
==About this Structure==
==About this Structure==
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1S6O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6O OCA].
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1S6O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6O OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:10:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:25:05 2008''

Revision as of 05:25, 28 July 2008

Image:1s6o.png

Template:STRUCTURE 1s6o

Solution structure and backbone dynamics of the apo-form of the second metal-binding domain of the Menkes protein ATP7A

Template:ABSTRACT PUBMED 15035611

About this Structure

1S6O is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and backbone dynamics of the Cu(I) and apo forms of the second metal-binding domain of the Menkes protein ATP7A., Banci L, Bertini I, Del Conte R, D'Onofrio M, Rosato A, Biochemistry. 2004 Mar 30;43(12):3396-403. PMID:15035611

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