1ttx

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[[Image:1ttx.gif|left|200px]]
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{{Seed}}
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[[Image:1ttx.png|left|200px]]
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{{STRUCTURE_1ttx| PDB=1ttx | SCENE= }}
{{STRUCTURE_1ttx| PDB=1ttx | SCENE= }}
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'''Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy'''
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===Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy===
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==Overview==
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The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15610002}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15610002 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15610002}}
==About this Structure==
==About this Structure==
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1TTX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA].
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1TTX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:24:52 2008''

Revision as of 14:24, 27 July 2008

Image:1ttx.png

Template:STRUCTURE 1ttx

Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy

Template:ABSTRACT PUBMED 15610002

About this Structure

1TTX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs., Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A, Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002

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