6gjq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human NBD1 of CFTR in complex with nanobody T27== | |
| - | + | <StructureSection load='6gjq' size='340' side='right'caption='[[6gjq]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gjq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GJQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Channel-conductance-controlling_ATPase Channel-conductance-controlling ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.49 3.6.3.49] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gjq OCA], [http://pdbe.org/6gjq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gjq RCSB], [http://www.ebi.ac.uk/pdbsum/6gjq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gjq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q20BJ8_HUMAN Q20BJ8_HUMAN]] Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.[RuleBase:RU362037] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Channel-conductance-controlling ATPase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Garcia-Pino, A]] | ||
| + | [[Category: Govaerts, C]] | ||
| + | [[Category: Grodecka, M]] | ||
| + | [[Category: He, L]] | ||
| + | [[Category: Hildebrandt, E]] | ||
| + | [[Category: Laeremans, T]] | ||
| + | [[Category: Overtus, M]] | ||
| + | [[Category: Pardon, E]] | ||
| + | [[Category: Riordan, J R]] | ||
| + | [[Category: Scholl, D]] | ||
| + | [[Category: Sigoillot, M]] | ||
| + | [[Category: Steyaert, J]] | ||
| + | [[Category: Urbatsch, I]] | ||
| + | [[Category: Cftr]] | ||
| + | [[Category: Conformational dynamic]] | ||
| + | [[Category: Cystic fibrosis]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nanobody]] | ||
| + | [[Category: Thermal stabilization]] | ||
Revision as of 05:52, 19 June 2019
human NBD1 of CFTR in complex with nanobody T27
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Categories: Channel-conductance-controlling ATPase | Large Structures | Garcia-Pino, A | Govaerts, C | Grodecka, M | He, L | Hildebrandt, E | Laeremans, T | Overtus, M | Pardon, E | Riordan, J R | Scholl, D | Sigoillot, M | Steyaert, J | Urbatsch, I | Cftr | Conformational dynamic | Cystic fibrosis | Hydrolase | Nanobody | Thermal stabilization
