6gk4

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'''Unreleased structure'''
 
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The entry 6gk4 is ON HOLD until Paper Publication
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==Human NBD1 of CFTR in complex with nanobodies D12 and T8==
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<StructureSection load='6gk4' size='340' side='right'caption='[[6gk4]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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Authors: Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gk4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GK4 FirstGlance]. <br>
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Description: Human NBD1 of CFTR in complex with nanobodies D12 and T8
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Channel-conductance-controlling_ATPase Channel-conductance-controlling ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.49 3.6.3.49] </span></td></tr>
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[[Category: Laeremans, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gk4 OCA], [http://pdbe.org/6gk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gk4 RCSB], [http://www.ebi.ac.uk/pdbsum/6gk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gk4 ProSAT]</span></td></tr>
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[[Category: Urbatsch, I]]
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</table>
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[[Category: Steyaert, J]]
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== Function ==
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[[Category: Sigoillot, M]]
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[[http://www.uniprot.org/uniprot/Q20BJ8_HUMAN Q20BJ8_HUMAN]] Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.[RuleBase:RU362037]
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__TOC__
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</StructureSection>
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[[Category: Channel-conductance-controlling ATPase]]
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[[Category: Large Structures]]
[[Category: Garcia-Pino, A]]
[[Category: Garcia-Pino, A]]
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[[Category: Govaerts, C]]
[[Category: Grodecka, M]]
[[Category: Grodecka, M]]
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[[Category: Pardon, E]]
 
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[[Category: Govaerts, C]]
 
[[Category: He, L]]
[[Category: He, L]]
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[[Category: Riordan, J.R]]
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[[Category: Hildebrandt, E]]
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[[Category: Laeremans, T]]
[[Category: Overtus, M]]
[[Category: Overtus, M]]
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[[Category: Hildebrandt, E]]
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[[Category: Pardon, E]]
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[[Category: Riordan, J R]]
[[Category: Scholl, D]]
[[Category: Scholl, D]]
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[[Category: Sigoillot, M]]
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[[Category: Steyaert, J]]
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[[Category: Urbatsch, I]]
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[[Category: Cftr]]
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[[Category: Conformational dynamic]]
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[[Category: Cystic fibrosis]]
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[[Category: Hydrolase]]
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[[Category: Nanobody]]
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[[Category: Thermal stabilization]]

Revision as of 05:52, 19 June 2019

Human NBD1 of CFTR in complex with nanobodies D12 and T8

PDB ID 6gk4

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