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6okp

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'''Unreleased structure'''
 
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The entry 6okp is ON HOLD until Paper Publication
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==B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074==
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<StructureSection load='6okp' size='340' side='right'caption='[[6okp]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related bNAbs with up to 62% neutralization breadth from an HIV-infected donor. SF12 recognized a glycan-dominated epitope on Env's silent face and was potent against clade AE viruses, which are poorly covered by V3-glycan bNAbs. A 3.3A cryo-EM structure of a SF12-Env trimer complex showed additional contacts to Env protein residues by SF12 compared with VRC-PG05, the only other known donor-derived silentface antibody, explaining SF12's increased neutralization breadth, potency, and resistance to Env mutation routes. Asymmetric binding of SF12 was associated with distinct N-glycan conformations across Env protomers, demonstrating intra-Env glycan heterogeneity. Administrating SF12 to HIV-1-infected humanized mice suppressed viremia and selected for viruses lacking the N448gp120 glycan. Effective bNAbs can therefore be raised against HIV-1 Env's silent face, suggesting their potential for HIV-1 prevention, therapy, and vaccine development.
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Authors: Barnes, C.O., Bjorkman, P.J.
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Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.,Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ Immunity. 2019 May 14. pii: S1074-7613(19)30194-3. doi:, 10.1016/j.immuni.2019.04.014. PMID:31126879<ref>PMID:31126879</ref>
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Description: B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Barnes, C.O]]
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<div class="pdbe-citations 6okp" style="background-color:#fffaf0;"></div>
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[[Category: Bjorkman, P.J]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Barnes, C O]]
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[[Category: Bjorkman, P J]]
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[[Category: Env trimer structure]]
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[[Category: Hiv-1 broadly-neutralizing antibody]]
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[[Category: Silent face]]
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[[Category: Viral protein-immune system complex]]

Revision as of 22:52, 5 June 2019

B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074

PDB ID 6okp

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