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1w6v

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[[Image:1w6v.gif|left|200px]]
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{{STRUCTURE_1w6v| PDB=1w6v | SCENE= }}
{{STRUCTURE_1w6v| PDB=1w6v | SCENE= }}
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'''SOLUTION STRUCTURE OF THE DUSP DOMAIN OF HUSP15'''
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===SOLUTION STRUCTURE OF THE DUSP DOMAIN OF HUSP15===
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==Overview==
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Ubiquitin-specific proteases (USPs) can remove covalently attached ubiquitin moieties from target proteins and regulate both the stability and ubiquitin-signaling state of their substrates. All USPs contain a conserved catalytic domain surrounded by one or more subdomains, some of which contribute to target recognition. One such specific subdomain, the DUSP domain (domain present in ubiquitin-specific proteases), is present in at least seven different human USPs that regulate the stability of or interact with the hypoxia-inducible transcription factor HIF1-alpha, the Von Hippel-Lindau protein (pVHL), cullin E3 ligases, and BRCA2. We describe the NMR solution structure of the DUSP domain of human USP15, recently implicated in COP9 (constitutive photomorphogenic gene 9)-signalosome regulation. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet. The DUSP domain displays a novel fold, an alpha/beta tripod (AB3). DUSP domain surface properties and previously described work suggest a potential role in protein/protein interaction or substrate recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_16298993}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16298993 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16298993}}
==About this Structure==
==About this Structure==
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1W6V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6V OCA].
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1W6V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6V OCA].
==Reference==
==Reference==
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[[Category: Usp]]
[[Category: Usp]]
[[Category: Usp15]]
[[Category: Usp15]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:13:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:07:08 2008''

Revision as of 13:07, 27 July 2008

Image:1w6v.png

Template:STRUCTURE 1w6v

SOLUTION STRUCTURE OF THE DUSP DOMAIN OF HUSP15

Template:ABSTRACT PUBMED 16298993

About this Structure

1W6V is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the human ubiquitin-specific protease 15 DUSP domain., de Jong RN, Ab E, Diercks T, Truffault V, Daniels M, Kaptein R, Folkers GE, J Biol Chem. 2006 Feb 24;281(8):5026-31. Epub 2005 Nov 18. PMID:16298993

Page seeded by OCA on Sun Jul 27 16:07:08 2008

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