6rj5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PHGDH in complex with compound 39== | |
| - | + | <StructureSection load='6rj5' size='340' side='right'caption='[[6rj5]], [[Resolution|resolution]] 1.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6rj5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJ5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K5N:2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide'>K5N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rj5 OCA], [http://pdbe.org/6rj5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rj5 RCSB], [http://www.ebi.ac.uk/pdbsum/6rj5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rj5 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bader, G]] | ||
| + | [[Category: Wolkerstorfer, B]] | ||
| + | [[Category: Zoephel, A]] | ||
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Protein-ligand complex]] | ||
Revision as of 06:06, 7 August 2019
Crystal structure of PHGDH in complex with compound 39
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