6rjp
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Bfl-1 in complex with alpha helical peptide== | |
- | + | <StructureSection load='6rjp' size='340' side='right'caption='[[6rjp]], [[Resolution|resolution]] 2.57Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[6rjp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJP FirstGlance]. <br> | |
- | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=LV8:'>LV8</scene></td></tr> | |
- | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjp OCA], [http://pdbe.org/6rjp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rjp RCSB], [http://www.ebi.ac.uk/pdbsum/6rjp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjp ProSAT]</span></td></tr> |
+ | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
[[Category: Baggio, C]] | [[Category: Baggio, C]] | ||
+ | [[Category: Gambini, L]] | ||
+ | [[Category: Hakansson, M]] | ||
+ | [[Category: Jossart, J]] | ||
[[Category: Pellecchia, M]] | [[Category: Pellecchia, M]] | ||
- | [[Category: | + | [[Category: Perry, J]] |
- | + | [[Category: Salem, A F]] | |
- | [[Category: Salem, A | + | |
[[Category: Udompholkul, P]] | [[Category: Udompholkul, P]] | ||
- | [[Category: | + | [[Category: Bcl2-2 family protein]] |
- | [[Category: | + | [[Category: Covalent inhibitor]] |
+ | [[Category: Peptide binding protein]] | ||
+ | [[Category: Protein-protein interaction]] | ||
+ | [[Category: Stapled alpha helix]] |
Revision as of 09:08, 30 October 2019
Bfl-1 in complex with alpha helical peptide
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