6rjv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex== |
| + | <StructureSection load='6rjv' size='340' side='right'caption='[[6rjv]], [[Resolution|resolution]] 3.21Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjv OCA], [http://pdbe.org/6rjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rjv RCSB], [http://www.ebi.ac.uk/pdbsum/6rjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ALBU_BOVIN ALBU_BOVIN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin. | ||
| - | + | Structural Characterization of a Gold/Serum Albumin Complex.,Pratesi A, Cirri D, Fregona D, Ferraro G, Giorgio A, Merlino A, Messori L Inorg Chem. 2019 Jul 30. doi: 10.1021/acs.inorgchem.9b01900. PMID:31361466<ref>PMID:31361466</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6rjv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ferraro, G]] | [[Category: Ferraro, G]] | ||
| - | [[Category: Merlino, A]] | ||
[[Category: Giorgio, A]] | [[Category: Giorgio, A]] | ||
| + | [[Category: Merlino, A]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 16:44, 14 August 2019
The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex
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