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| | <StructureSection load='6hyf' size='340' side='right'caption='[[6hyf]], [[Resolution|resolution]] 1.60Å' scene=''> | | <StructureSection load='6hyf' size='340' side='right'caption='[[6hyf]], [[Resolution|resolution]] 1.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6hyf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6hyf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HYF FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyf OCA], [http://pdbe.org/6hyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyf RCSB], [http://www.ebi.ac.uk/pdbsum/6hyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyf ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyf OCA], [https://pdbe.org/6hyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hyf RCSB], [https://www.ebi.ac.uk/pdbsum/6hyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyf ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/ITB4_RAT ITB4_RAT]] Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.[UniProtKB:P16144] | + | [https://www.uniprot.org/uniprot/ITB4_RAT ITB4_RAT] Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.[UniProtKB:P16144] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6hyf" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6hyf" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Integrin 3D structures|Integrin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Kursula, P]] | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Raasakka, A]] | + | [[Category: Kursula P]] |
| - | [[Category: Integrin]] | + | [[Category: Raasakka A]] |
| - | [[Category: Myelin]]
| + | |
| - | [[Category: Periaxin]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| Structural highlights
Function
ITB4_RAT Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.[UniProtKB:P16144]
Publication Abstract from PubMed
The process of myelination in the nervous system requires a coordinated formation of both transient and stable supramolecular complexes. Myelin-specific proteins play key roles in these assemblies, which may link membranes to each other or connect the myelinating cell cytoskeleton to the extracellular matrix. The myelin protein periaxin is known to play an important role in linking the Schwann cell cytoskeleton to the basal lamina through membrane receptors, such as the dystroglycan complex. Mutations that truncate periaxin from the C terminus cause demyelinating peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease type 4F, indicating a function for the periaxin C-terminal region in myelination. We identified the cytoplasmic domain of beta4 integrin as a specific high-affinity binding partner for periaxin. The C-terminal region of periaxin remains unfolded and flexible when bound to the third fibronectin type III domain of beta4 integrin. Our data suggest that periaxin is able to link the Schwann cell cytoplasm to the basal lamina through a two-pronged interaction via different membrane protein complexes, which bind close to the N and C terminus of this elongated, flexible molecule.
Direct Binding of the Flexible C-Terminal Segment of Periaxin to beta4 Integrin Suggests a Molecular Basis for CMT4F.,Raasakka A, Linxweiler H, Brophy PJ, Sherman DL, Kursula P Front Mol Neurosci. 2019 Apr 9;12:84. doi: 10.3389/fnmol.2019.00084. eCollection , 2019. PMID:31024253[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Raasakka A, Linxweiler H, Brophy PJ, Sherman DL, Kursula P. Direct Binding of the Flexible C-Terminal Segment of Periaxin to beta4 Integrin Suggests a Molecular Basis for CMT4F. Front Mol Neurosci. 2019 Apr 9;12:84. doi: 10.3389/fnmol.2019.00084. eCollection , 2019. PMID:31024253 doi:http://dx.doi.org/10.3389/fnmol.2019.00084
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