2jex

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<StructureSection load='2jex' size='340' side='right'caption='[[2jex]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='2jex' size='340' side='right'caption='[[2jex]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]], [[2jeu|2jeu]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]], [[2jeu|2jeu]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [http://pdbe.org/2jex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [http://www.ebi.ac.uk/pdbsum/2jex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jex ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [https://pdbe.org/2jex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [https://www.ebi.ac.uk/pdbsum/2jex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jex ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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[[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2jex" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2jex" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
== References ==
== References ==
<references/>
<references/>

Revision as of 11:26, 31 March 2021

Transcription activator structure reveals redox control of a replication initiation reaction

PDB ID 2jex

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