2yin

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<StructureSection load='2yin' size='340' side='right'caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2yin' size='340' side='right'caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YIN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vrw|2vrw]], [[1e96|1e96]], [[1i4d|1i4d]], [[1foe|1foe]], [[1mh1|1mh1]], [[1i4l|1i4l]], [[1he1|1he1]], [[1ryf|1ryf]], [[2wkq|2wkq]], [[1ryh|1ryh]], [[1hh4|1hh4]], [[2wkr|2wkr]], [[2wkp|2wkp]], [[2fju|2fju]], [[1g4u|1g4u]], [[1i4t|1i4t]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vrw|2vrw]], [[1e96|1e96]], [[1i4d|1i4d]], [[1foe|1foe]], [[1mh1|1mh1]], [[1i4l|1i4l]], [[1he1|1he1]], [[1ryf|1ryf]], [[2wkq|2wkq]], [[1ryh|1ryh]], [[1hh4|1hh4]], [[2wkr|2wkr]], [[2wkp|2wkp]], [[2fju|2fju]], [[1g4u|1g4u]], [[1i4t|1i4t]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [http://pdbe.org/2yin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [http://www.ebi.ac.uk/pdbsum/2yin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yin ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [https://pdbe.org/2yin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [https://www.ebi.ac.uk/pdbsum/2yin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yin ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN]] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref> [[http://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN]] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref>
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[[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN]] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref> [[https://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN]] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dedicator of cytokinesis protein|Dedicator of cytokinesis protein]]
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*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
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*[[Rac|Rac]]
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*[[Rac 3D structures|Rac 3D structures]]
== References ==
== References ==
<references/>
<references/>

Revision as of 15:05, 17 November 2021

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

PDB ID 2yin

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