1z2g

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[[Image:1z2g.gif|left|200px]]
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{{STRUCTURE_1z2g| PDB=1z2g | SCENE= }}
{{STRUCTURE_1z2g| PDB=1z2g | SCENE= }}
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'''Solution structure of apo, oxidized yeast Cox17'''
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===Solution structure of apo, oxidized yeast Cox17===
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==Overview==
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Cox17 is a key mitochondrial copper chaperone involved in the assembly of cytochrome c oxidase (COX). The NMR solution structure of the oxidized apoCox17 isoform consists of a coiled-coil conformation stabilized by two disulfide bonds involving Cys(26)/Cys(57) and Cys(36)/Cys(47). This appears to be a conserved tertiary fold of a class of proteins, localized within the mitochondrial intermembrane space, that contain a twin Cys-x(9)-Cys sequence motif. An isomerization of one disulfide bond from Cys(26)/Cys(57) to Cys(24)/Cys(57) is required prior to Cu(I) binding to form the Cu(1)Cox17 complex. Upon further oxidation of the apo-protein, a form with three disulfide bonds is obtained. The reduction of all disulfide bonds provides a molten globule form that can convert to an additional conformer capable of binding up to four Cu(I) ions in a polycopper cluster. This form of the protein is oligomeric. These properties are framed within a complete model of mitochondrial import and COX assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 15893662 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893662}}
==About this Structure==
==About this Structure==
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1Z2G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2G OCA].
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1Z2G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2G OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:16:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:10:51 2008''

Revision as of 10:10, 28 July 2008

Image:1z2g.png

Template:STRUCTURE 1z2g

Solution structure of apo, oxidized yeast Cox17

Template:ABSTRACT PUBMED 15893662

About this Structure

1Z2G is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding., Arnesano F, Balatri E, Banci L, Bertini I, Winge DR, Structure. 2005 May;13(5):713-22. PMID:15893662

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