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4u5u

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<StructureSection load='4u5u' size='340' side='right'caption='[[4u5u]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='4u5u' size='340' side='right'caption='[[4u5u]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U5U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3D2:N~2~-[3-(PYRIDIN-3-YL)BENZYL]-L-LYSINAMIDE'>3D2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D2:N~2~-[3-(PYRIDIN-3-YL)BENZYL]-L-LYSINAMIDE'>3D2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5u OCA], [https://pdbe.org/4u5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5u RCSB], [https://www.ebi.ac.uk/pdbsum/4u5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5u OCA], [http://pdbe.org/4u5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u5u RCSB], [http://www.ebi.ac.uk/pdbsum/4u5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4u5u" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4u5u" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Holvey, R S]]
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[[Category: Holvey RS]]
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[[Category: Stewart, M]]
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[[Category: Stewart M]]
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[[Category: Valkov, E]]
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[[Category: Valkov E]]
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[[Category: Tpx2]]
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[[Category: Transport protein]]
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Revision as of 08:04, 22 March 2023

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

PDB ID 4u5u

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