4u6k
From Proteopedia
(Difference between revisions)
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<StructureSection load='4u6k' size='340' side='right'caption='[[4u6k]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='4u6k' size='340' side='right'caption='[[4u6k]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4u6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6K OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4u6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U6K FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> |
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCU:[(1R,5R,7R,8S)-7-(4-AMINO-5-METHYL-2-OXOPYRIMIDIN-1(2H)-YL)-8-HYDROXY-3-METHYL-2,6-DIOXA-3-AZABICYCLO[3.2.1]OCT-5-YL]METHYL+DIHYDROGEN+PHOSPHATE'>NCU</scene>, <scene name='pdbligand=NTT:[(1R,5R,7R,8S)-8-HYDROXY-3-METHYL-7-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2,6-DIOXA-3-AZABICYCLO[3.2.1]OCT-5-YL]METHYL+DIHYDROGEN+PHOSPHATE'>NTT</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCU:[(1R,5R,7R,8S)-7-(4-AMINO-5-METHYL-2-OXOPYRIMIDIN-1(2H)-YL)-8-HYDROXY-3-METHYL-2,6-DIOXA-3-AZABICYCLO[3.2.1]OCT-5-YL]METHYL+DIHYDROGEN+PHOSPHATE'>NCU</scene>, <scene name='pdbligand=NTT:[(1R,5R,7R,8S)-8-HYDROXY-3-METHYL-7-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2,6-DIOXA-3-AZABICYCLO[3.2.1]OCT-5-YL]METHYL+DIHYDROGEN+PHOSPHATE'>NTT</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u6l|4u6l]], [[4u6m|4u6m]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4u6l|4u6l]], [[4u6m|4u6m]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6k OCA], [https://pdbe.org/4u6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u6k RCSB], [https://www.ebi.ac.uk/pdbsum/4u6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u6k ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties. | ||
| + | |||
| + | The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.,Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H Chem Commun (Camb). 2016 Feb 7;52(11):2354-7. doi: 10.1039/c5cc08300a. PMID:26731288<ref>PMID:26731288</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4u6k" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 16:17, 6 July 2022
Crystal structure of DNA/RNA duplex containing 2'-4'-BNA-NC
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