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4tpt

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<StructureSection load='4tpt' size='340' side='right'caption='[[4tpt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4tpt' size='340' side='right'caption='[[4tpt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tpt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tpt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TPT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35H:N-{4-[(1S)-1,2-DIHYDROXYETHYL]BENZYL}-N-METHYL-4-(PHENYLSULFAMOYL)BENZAMIDE'>35H</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35H:N-{4-[(1S)-1,2-DIHYDROXYETHYL]BENZYL}-N-METHYL-4-(PHENYLSULFAMOYL)BENZAMIDE'>35H</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIMK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpt OCA], [https://pdbe.org/4tpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tpt RCSB], [https://www.ebi.ac.uk/pdbsum/4tpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpt ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpt OCA], [http://pdbe.org/4tpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tpt RCSB], [http://www.ebi.ac.uk/pdbsum/4tpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpt ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LIMK2_HUMAN LIMK2_HUMAN]] Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.<ref>PMID:10436159</ref> <ref>PMID:11018042</ref>
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[https://www.uniprot.org/uniprot/LIMK2_HUMAN LIMK2_HUMAN] Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.<ref>PMID:10436159</ref> <ref>PMID:11018042</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Burgoon HA]]
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[[Category: Burgoon, H A]]
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[[Category: Cianchetta G]]
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[[Category: Cianchetta, G]]
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[[Category: Goodwin NC]]
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[[Category: Goodwin, N C]]
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[[Category: Hamman BL]]
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[[Category: Hamman, B L]]
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[[Category: Healy J]]
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[[Category: Healy, J]]
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[[Category: Mabon S]]
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[[Category: Mabon, S]]
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[[Category: Rawlins DB]]
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[[Category: Rawlins, D B]]
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[[Category: Strobel ED]]
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[[Category: Strobel, E D]]
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[[Category: Wang S]]
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[[Category: Wang, S]]
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[[Category: Dfg inhibitor]]
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[[Category: Limk2 kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 10:48, 15 March 2023

Crystal Structure of the Human LIMK2 Kinase Domain In Complex With a Non-ATP Competitive Inhibitor

PDB ID 4tpt

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