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4twl
From Proteopedia
(Difference between revisions)
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<StructureSection load='4twl' size='340' side='right'caption='[[4twl]], [[Resolution|resolution]] 2.11Å' scene=''> | <StructureSection load='4twl' size='340' side='right'caption='[[4twl]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4twl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4twl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioscorea_japonica Dioscorea japonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASC:ASCORBIC+ACID'>ASC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASC:ASCORBIC+ACID'>ASC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twl OCA], [https://pdbe.org/4twl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twl RCSB], [https://www.ebi.ac.uk/pdbsum/4twl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twl ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DIOA3_DIOJA DIOA3_DIOJA] Storage protein of tuber. Involved in protection against oxidative stress (Probable). Has carbonate dehydratase, trypsin inhibitor, dehydroascorbate (DHA) reductase and monodehydroascorbate (MDA) reductase activities (PubMed:22195572). Catalyzes the reactions of carbonate dehydratase and DHA reductase independently of zinc and glutathione (GSH). The coupled reaction is capable of recycling a plant antioxidant ascorbate using ubiquitous compounds H(2)O and CO(2) (PubMed:25747844). Exhibits antioxidant activity. Able to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Exhibits immunomodulatory activity. Activates Toll-like receptor 4 signaling pathways by up-regulating the gene expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1 beta and interleukin-6, and chemokines RANTES and MCP-1, in mouse RAW 264.7 macrophages. Stimulates the phagocytosis of E.coli by the LPS-treated mouse macrophages (PubMed:22796748).<ref>PMID:22195572</ref> <ref>PMID:22796748</ref> <ref>PMID:25747844</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Dioscorea japonica]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Miyakawa | + | [[Category: Miyakawa T]] |
| - | [[Category: Nakamura | + | [[Category: Nakamura A]] |
| - | [[Category: Tanokura | + | [[Category: Tanokura M]] |
| - | [[Category: Xue | + | [[Category: Xue YL]] |
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Current revision
Crystal structure of dioscorin complexed with ascorbate
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