Complement C3

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== Function ==
== Function ==
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'''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
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'''Complement C3''' (CC3) activates the complement system which is part of the immune response. '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663).
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*'''C3a''' is a mediator of local inflammatory processes.
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*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
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*Breakdown of C3b generates the fragment '''C3d''' (residues 996-1287) which binds to antigens enhancing their uptake by B cells.
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*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.
<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.

Revision as of 08:52, 5 June 2024

Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code 2icf).

Drag the structure with the mouse to rotate

References

  1. ↑ Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev. 2001 Apr;180:35-48. PMID:11414361
  2. ↑ Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:17051150 doi:10.1038/nature05263

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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