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Haptoglobin receptor
From Proteopedia
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<StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'> | <StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'> | ||
== Function == | == Function == | ||
| - | '''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | + | '''Haptoglobin receptor''' or '''Iron-regulated surface determinant protein H''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. |
*<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]]) | *<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]]) | ||
*<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>. | *<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>. | ||
Revision as of 07:21, 22 August 2021
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3D Structures of haptoglobin receptor
Updated on 22-August-2021
References
- ↑ Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296. PMID:18451305 doi:http://dx.doi.org/10.1126/science.1156296
