Complement factor
From Proteopedia
(Difference between revisions)
| Line 21: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
| - | |||
| - | ==3D structures of complement factor== | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Complement factor B | ||
| - | |||
| - | **[[2ok5]] – hCFB residues 26-764<br /> | ||
| - | **[[1dle]] – hCFB serine protease domain residues 470-764<br /> | ||
| - | **[[1q0p]] – hCFB residues 254-476 (mutant) <br /> | ||
| - | **[[1rrk]] – hCFB BB fragment residues 243-764 (mutant) <br /> | ||
| - | |||
| - | *Complement factor B complexes | ||
| - | |||
| - | **[[1rs0]] – hCFB BB fragment (mutant) + DIP<br /> | ||
| - | **[[1rtk]] – hCFB BB fragment (mutant) + guanidinobenzoate<br /> | ||
| - | **[[5m6w]] – hCFB + complement C3 α+β chains<br /> | ||
| - | **[[2xwj]] – hCFB (mutant) + complement C3 α+β chains<br /> | ||
| - | **[[2xwb]] – hCFB (mutant) + hCFD (mutant) + complement C3 α+β chains<br /> | ||
| - | **[[3hrz]], [[3hs0]] – hCFB (mutant) + cobra venom factor<br /> | ||
| - | |||
| - | *Complement factor D | ||
| - | |||
| - | **[[1dsu]], [[1hfd]] – hCFD <br /> | ||
| - | **[[1dst]], [[2xw9]], [[2xwa]], [[4cbn]], [[4cbo]] – hCFD (mutant) <br /> | ||
| - | **[[1fdp]] – hCFD proenzyme <br /> | ||
| - | |||
| - | *Complement factor D complexes | ||
| - | |||
| - | **[[1bio]], [[1dfp]], [[1dic]], [[5fbe]], [[5fbi]], [[5fck]], [[5fcr]], [[5mt0]], [[5mt4]], [[5nar]], [[5nat]], [[5naw]], [[5nb6]], [[5nb7]], [[5nba]], [[5tca]], [[5tcc]],[[6qmr]], [[6qmt]], [[6fut]], [[6fuj]], [[6fui]], [[6fuh]], [[6fug]], [[6ftz]], [[6fty]] – hCFD + inhibitor <br /> | ||
| - | **[[4d9r]] – hCFD + antibody<br /> | ||
| - | |||
| - | *Complement factor H | ||
| - | |||
| - | **[[1haq]], [[3gau]], [[3gav]], [[3gaw]] – hCFH – human - NMR<br /> | ||
| - | **[[2rlp]] – hCFH 1-2 sushi domains - NMR <br /> | ||
| - | **[[2rlq]] – hCFH 2-3 sushi domains - NMR <br /> | ||
| - | **[[2qfg]] – hCFH 1-5 sushi domains <br /> | ||
| - | **[[2yby]] – mCFH 6-8 sushi domains (mutant) - mouse<br /> | ||
| - | **[[2ic4]] – hCFH 6-8 sushi domains (mutant) <br /> | ||
| - | **[[2jgw]] – hCFH 7 sushi domain – NMR<br /> | ||
| - | **[[2jgx]] – hCFH 7 sushi domain (mutant) <br /> | ||
| - | **[[4b2r]] – hCFH 10-11 sushi domains - NMR <br /> | ||
| - | **[[4b2s]] – hCFH 11-12 sushi domains - NMR <br /> | ||
| - | **[[2kms]] – hCFH 12-13 sushi domains – NMR<br /> | ||
| - | **[[1hfi]] – hCFH 15 sushi domain – NMR<br /> | ||
| - | **[[1hfh]] – hCFH 15-16 sushi domains – NMR<br /> | ||
| - | **[[2qfh]] – hCFH 16-20 sushi domains - NMR <br /> | ||
| - | **[[3sw0]] – hCFH 18-20 sushi domains <br /> | ||
| - | **[[2bzm]] – hCFH 19-20 sushi domains – NMR<br /> | ||
| - | **[[3kzj]] – hCFH 19-20 sushi domains (mutant) – NMR<br /> | ||
| - | **[[2g7i]] – hCFH 19-20 sushi domains <br /> | ||
| - | **[[3kxv]], [[3r62]] – hCFH 19-20 sushi domains (mutant) <br /> | ||
| - | |||
| - | *Complement factor H complexes | ||
| - | |||
| - | **[[2wii]] – hCFH 1-4 sushi domains + complement C3 <br /> | ||
| - | **[[2w80]], [[2w81]], [[4ayd]], [[4aye]], [[4ayi]], [[4aym]] – hCFH 6-7 sushi domains + factor H binding protein <br /> | ||
| - | **[[2uwn]], [[2v8e]] – hCFH 6-8 sushi domains + sucrose octasulfate <br /> | ||
| - | **[[4k12]] – hCFH 9 sushi domain + choline binding protein A <br /> | ||
| - | **[[3oxu]], [[4ont]], [[4zh1]] – hCFH 19-20 sushi domains + complement C3 <br /> | ||
| - | **[[2xqw]] – hCFH 19-20 sushi domains (mutant) + complement C3 <br /> | ||
| - | **[[4j38]] – hCFH 19-20 sushi domains (mutant) + outer surface protein E <br /> | ||
| - | **[[4k12]] – hCFH 9 sushi domain + choline binding protein A <br /> | ||
| - | **[[5nbq]] – hCFH + complement C3 α chain + outer surface protein<br /> | ||
| - | **[[5o32]] – hCFH + hCFI + complement C3 α+β chains <br /> | ||
| - | **[[5o35]] – hCFH + complement C3 α chain <br /> | ||
| - | |||
| - | *Complement factor I | ||
| - | |||
| - | **[[2xrc]] – hCFI <br /> | ||
| - | |||
| - | }} | ||
| - | |||
| - | |||
| - | |||
== References == | == References == | ||
Revision as of 08:08, 15 May 2019
| |||||||||||
References
- ↑ Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol. 2004 Jun;41(4):355-67. PMID:15163532 doi:10.1016/j.molimm.2004.02.005
- ↑ Stanton CM, Yates JR, den Hollander AI, Seddon JM, Swaroop A, Stambolian D, Fauser S, Hoyng C, Yu Y, Atsuhiro K, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore AT, Dhillon B, Ueffing M, Wright AF. Complement factor D in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8828-34. doi: 10.1167/iovs.11-7933. PMID:22003108 doi:http://dx.doi.org/10.1167/iovs.11-7933
- ↑ Alexander P, Gibson J, Cree AJ, Ennis S, Lotery AJ. Complement factor I and age-related macular degeneration. Mol Vis. 2014 Sep 13;20:1253-7. eCollection 2014. PMID:25352734
- ↑ Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Proce S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ. Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09242. doi:, 10.1161/HYPERTENSIONAHA.117.09242. PMID:28739975 doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09242
