Hemagglutinin-esterase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>. | The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>. | ||
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| + | ==3D structures of hemagglutinin-esterase== | ||
| + | [[Hemagglutinin-esterase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of hemagglutinin-esterase== | ==3D structures of hemagglutinin-esterase== | ||
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**[[3i26]] – BtHE – bovine torovirus<br /> | **[[3i26]] – BtHE – bovine torovirus<br /> | ||
**[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br /> | **[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br /> | ||
| - | **[[5t9y]] – savHE – salmon anemia virus<br /> | + | **[[5t9y]], [[5t96]] – savHE – salmon anemia virus<br /> |
**[[5n11]] – HE – human corona virus<br /> | **[[5n11]] – HE – human corona virus<br /> | ||
**[[5jif]] – HE – murine corona virus<br /> | **[[5jif]] – HE – murine corona virus<br /> | ||
Revision as of 08:22, 24 July 2019
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3D structures of hemagglutinin-esterase
Updated on 24-July-2019
References
- ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
- ↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492
