6k18
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of EXD2 exonuclease domain soaked in Mn== | |
| - | + | <StructureSection load='6k18' size='340' side='right'caption='[[6k18]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6k18]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K18 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k18 OCA], [http://pdbe.org/6k18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k18 RCSB], [http://www.ebi.ac.uk/pdbsum/6k18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k18 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EXD2_HUMAN EXD2_HUMAN]] Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.<ref>PMID:20603073</ref> <ref>PMID:26807646</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Exodeoxyribonuclease I]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lee, C]] | [[Category: Lee, C]] | ||
[[Category: Park, J]] | [[Category: Park, J]] | ||
| + | [[Category: 3'-5' exonuclease]] | ||
| + | [[Category: Dnaq family]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 06:51, 23 May 2019
Crystal structure of EXD2 exonuclease domain soaked in Mn
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