This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6k19
From Proteopedia
(Difference between revisions)
m (Protected "6k19" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of EXD2 exonuclease domain soaked in Mg== | |
| - | + | <StructureSection load='6k19' size='340' side='right'caption='[[6k19]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6k19]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K19 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k19 OCA], [http://pdbe.org/6k19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k19 RCSB], [http://www.ebi.ac.uk/pdbsum/6k19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k19 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EXD2_HUMAN EXD2_HUMAN]] Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.<ref>PMID:20603073</ref> <ref>PMID:26807646</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Exodeoxyribonuclease I]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lee, C]] | [[Category: Lee, C]] | ||
[[Category: Park, J]] | [[Category: Park, J]] | ||
| + | [[Category: 3'-5' exonuclease]] | ||
| + | [[Category: Dnaq family]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 06:51, 23 May 2019
Crystal structure of EXD2 exonuclease domain soaked in Mg
| |||||||||||
