6ov7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CFTR Associated Ligand (CAL) PDZ domain bound to peptide kCAL01== | |
| - | + | <StructureSection load='6ov7' size='340' side='right'caption='[[6ov7]], [[Resolution|resolution]] 1.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ov7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OV7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ov7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov7 OCA], [http://pdbe.org/6ov7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ov7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ov7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov7 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gill, N P]] | ||
| + | [[Category: Madden, D R]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Peptide binding protein]] | ||
Revision as of 15:28, 20 November 2019
CFTR Associated Ligand (CAL) PDZ domain bound to peptide kCAL01
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