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4ud1

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Revision as of 08:17, 22 March 2023

Structure of the N Terminal domain of the MERS CoV nucleocapsid

Structural highlights

4ud1 is a 5 chain structure with sequence from Middle East respiratory syndrome-related coronavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

T2B9R0_MERS

Publication Abstract from PubMed

The N protein of coronaviruses is a multifunctional protein that is organized into several domains. The N-terminal part is composed of an intrinsically disordered region (IDR) followed by a structured domain called the N-terminal domain (NTD). In this study, the structure determination of the N-terminal region of the MERS-CoV N protein via X-ray diffraction measurements is reported at a resolution of 2.4 A. Since the first 30 amino acids were not resolved by X-ray diffraction, the structural study was completed by a SAXS experiment to propose a structural model including the IDR. This model presents the N-terminal region of the MERS-CoV as a monomer that displays structural features in common with other coronavirus NTDs.

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering.,Papageorgiou N, Lichiere J, Baklouti A, Ferron F, Sevajol M, Canard B, Coutard B Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):192-202. doi:, 10.1107/S2059798315024328. Epub 2016 Jan 22. PMID:26894667^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Papageorgiou N, Lichiere J, Baklouti A, Ferron F, Sevajol M, Canard B, Coutard B. Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering. Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):192-202. doi:, 10.1107/S2059798315024328. Epub 2016 Jan 22. PMID:26894667 doi:http://dx.doi.org/10.1107/S2059798315024328

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ud1"

@@ Line 3: / Line 3: @@
 <StructureSection load='4ud1' size='340' side='right'caption='[[4ud1]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ud1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UD1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ud1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UD1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ud1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ud1 OCA], [http://pdbe.org/4ud1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ud1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ud1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ud1 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ud1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ud1 OCA], [https://pdbe.org/4ud1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ud1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ud1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ud1 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/T2B9R0_MERS T2B9R0_MERS]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Mers]]
+[[Category: Middle East respiratory syndrome-related coronavirus]]
-[[Category: Canard, B]]
+[[Category: Canard B]]
-[[Category: Coutard, B]]
+[[Category: Coutard B]]
-[[Category: Ferron, F]]
+[[Category: Ferron F]]
-[[Category: Lichiere, J]]
+[[Category: Lichiere J]]
-[[Category: Papageorgiou, N]]
+[[Category: Papageorgiou N]]
-[[Category: Rna binding domain]]
-[[Category: Viral protein]]

4ud1

From Proteopedia

Revision as of 08:17, 22 March 2023

Structure of the N Terminal domain of the MERS CoV nucleocapsid

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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