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1b07
From Proteopedia
(Difference between revisions)
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<StructureSection load='1b07' size='340' side='right'caption='[[1b07]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='1b07' size='340' side='right'caption='[[1b07]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1b07]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B07 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[1b07]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B07 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYJ:PHENYLETHANE'>PYJ</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYJ:PHENYLETHANE'>PYJ</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b07 OCA], [https://pdbe.org/1b07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b07 RCSB], [https://www.ebi.ac.uk/pdbsum/1b07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b07 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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*[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]] | *[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]] | ||
*[[Non-Standard Residue|Non-Standard Residue]] | *[[Non-Standard Residue|Non-Standard Residue]] | ||
| - | *[[Unusual sequence numbering|Unusual sequence numbering]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 06:55, 24 February 2021
CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
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