6os1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023== | |
| - | + | <StructureSection load='6os1' size='340' side='right'caption='[[6os1]], [[Resolution|resolution]] 2.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6os1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OS1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6os1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6os1 OCA], [http://pdbe.org/6os1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6os1 RCSB], [http://www.ebi.ac.uk/pdbsum/6os1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6os1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN]] NON RARE IN EUROPE: Essential hypertension;Renal tubular dysgenesis of genetic origin. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN]] Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kleinhenz, A L.W]] | ||
| + | [[Category: Kruse, A C]] | ||
| + | [[Category: Lefkowitz, R J]] | ||
| + | [[Category: McMahon, C]] | ||
| + | [[Category: Skiba, M A]] | ||
| + | [[Category: Staus, D P]] | ||
| + | [[Category: Wingler, L M]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 06:25, 19 February 2020
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023
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