Cyclophilin

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== 3D Structures of Cyclophilin ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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* Cyclophilin-A or peptidyl-prolyl cis-trans isomerase A
 
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**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]], [[5kul]] – hCyp-A – human<br />
 
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**[[1oca]], [[2mzu]] – hCyp-A - NMR<br />
 
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**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] ,[[6bta]], [[5wc7]] – hCyp-A (mutant)<br />
 
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**[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br />
 
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**[[6fk1]] – mCyp-A – mouse<br />
 
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**[[1ist]] – yCyp-A – yeast<br />
 
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**[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br />
 
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**[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
 
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**[[4e1q]] – Cyp-A – wheat<br />
 
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**[[4eyv]] – Cyp-A – ''Piriformospora indica''<br />
 
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**[[5ex2]], [[5ex1]] – Cyp-A – ''Hirschia baltica''<br />
 
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* Cyclophilin-A complex
 
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**[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
 
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**[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
 
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**[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]], [[5hsv]] - hCyp-A+cyclosporin A derivative<br />
 
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**[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
 
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**[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
 
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**[[3odi]], [[3odl]] – hCyp-A+voclosporin<br />
 
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**[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
 
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**[[5fjb]] - hCyp-A + HIV-1 gag protein <br />
 
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**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
 
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**[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]] – hCyp-A+ sanglifehrin derivaive<br />
 
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**[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]], [[3rdd]], [[5noz]], [[5noy]], [[5nox]], [[5nou]], [[5nov]], [[5now]], [[5nor]], [[5nos]], [[5not]], [[5noq]], [[5lud]], [[6gji]], [[6gjj]], [[6gjl]], [[6gjm]], [[6gjn]], [[6gjp]], [[6gjr]], [[6gjy]] – hCyp-A + inhibitor<br />
 
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**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
 
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**[[1vbs]], [[1vbt]], [[2ms4]] – hCyp-A+tetrapeptide<br />
 
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**[[4ipz]] - hCyp-A (mutant) + peptide <br />
 
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**[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br />
 
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**[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br />
 
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**[[1vdn]] – yCyp-A+peptidyl coumarin <br />
 
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**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
 
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**[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
 
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**[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
 
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**[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
 
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**[[3pmp]] - NpCyp-A + cyclosporin A<br />
 
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**[[3t1u]] – Cyp-A + peptide – ''Azotobacter vinelandii''<br />
 
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* Cyclophilin-B
 
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**[[3ich]] – hCyp-B<br />
 
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**[[3ici]] - hCyp-B+calmegin fragment<br />
 
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**[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
 
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**[[1vai]] - EcCyp-B+peptidyl coumarin<br />
 
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**[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
 
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**[[2rs4]] – EcCyp-B - NMR<BR />
 
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**[[1j2a]] – EcCyp-B (mutant)<br />
 
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**[[4fru]] – hoCyp-B – horse<br />
 
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**[[4frv]] – hoCyp-B (mutant)<br />
 
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**[[1a58]], [[4jcp]] – Cyp-B – ''Brugia malayi''<br />
 
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* Cyclophilin-C
 
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**[[2esl]] - hCyp-C+cyclosporin A<br />
 
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**[[2rmc]] - mCyp-C+cyclosporin A <br />
 
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**[[1jns]], [[1jnt]] – EcCyp-C - NMR<BR />
 
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* Cyclophilin-D or peptidyl-prolyl cis-trans isomerase F
 
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**[[2bit]], [[3qyu]] – hCyp-D<br />
 
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**[[4zsd]], [[4o8i]], [[4o8h]] - hCyp-D (mutant) <br />
 
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**[[2biu]] – hCyp-D+DMSO<br />
 
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**[[2z6w]] - hCyp-D+cyclosporin A<br />
 
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**[[5a0e]] - hCyp-D (mutant) + cyclosporin A<br />
 
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**[[4tot]] – hCyp-D + polypeptide inhibitor<br />
 
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**[[5nwo]] – hCyp-D + inhibitor<br />
 
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**[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]], [[5ccs]], [[5ccr]], [[5ccq]], [[5ccn]], [[5cbw]], [[5cbv]], [[5cbu]], [[5cbt]], [[4zsc]], [[4xnc]], [[4j5e]] – hCyp-D (mutant) + inhibitor<br />
 
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* Cyclophilin-E or peptidyl-prolyl cis-trans isomerase E
 
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**[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
 
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**[[2r99]], [[3uch]] - hCyp-E ABH-like domain<br />
 
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**[[2cqb]] – hCyp-E RNA recognition motif<br />
 
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**[[2kyx]] – hCyp-E RRM domain – NMR<br />
 
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**[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
 
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**[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
 
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* Cyclophilin-G
 
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**[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
 
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**[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
 
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* Cyclophilin-H
 
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**[[1mzw]] – hCyp-H+peptide<br />
 
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* Cyclophilin-J
 
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**[[2ok3]], [[1xyh]] - hCyp-J<br />
 
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**[[2oju]] - hCyp-J+cyclosporin A<br />
 
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* Cyclophilin-3
 
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**[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
 
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**[[1dyw]] - CeCyp-3<br />
 
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**[[1e3b]] – CeCyp-3+AUP(ET)3<br />
 
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* Cyclophilin-5
 
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**[[1h0p]] – CeCyp-5 (mutant) <br />
 
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* Cyclophilin-38
 
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**[[3rfy]] – Cyp-38 – ''Arabidopsis thaliana''<br />
 
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* Cyclophilin-40
 
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**[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
 
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* Cyclophilin
 
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**[[1qoi]] – hCyp SNUCYP-20<br />
 
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**[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
 
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**[[2nul]] – EcCyp<br />
 
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**[[1clh]] – EcCyp – NMR<br />
 
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**[[3k2c]] – Cyp – ''Encephalitozoon cuniculi''<br />
 
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**[[3eov]] - LdCyp+cyclosporin A – ''Leishmania donovani''<br />
 
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**[[3bt8]] – LdCyp<br />
 
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**[[2haq]] – LdCyp-A<br />
 
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**[[2hqj]] – Cyp – ''Leishmania major''<br />
 
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**[[3bkp]] – TgCyp<br />
 
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**[[2cfe]] – Cyp – ''Malassezia sympodialis''<br />
 
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**[[2c3b]] – Cyp – ''Aspergillus fumigatus''<br />
 
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**[[1z81]] – Cyp – ''Plasmodium Yoelli''<br />
 
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**[[1qng]] – PfCyp+cyclosporin A – ''Plasmodium falciparum''<br />
 
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**[[1qnh]] – PfCyp (mutant)+cyclosporin A<br />
 
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**[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br />
 
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**[[1xq7]] - TcCyp+cyclosporin A<br />
 
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**[[2ko7]], [[2l2s]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
 
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**[[2ke0]], [[3s6m]] – BpCyp – NMR<br />
 
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**[[4dz2]], [[4dz3]] – BpPin1 (mutant) + FK506<BR />
 
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**[[2wlw]] - Cyp – macaca mulata <br />
 
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**[[2mc9]] - Cyp – rosy periwinkle <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:57, 22 May 2019

Human Cyclophilin-A (rust, olive, turquois, dark green, khaki) complex with cyclosporin A (green, cyan, aqua, neon green, blue) (PDB entry 2x2c)

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References

  1. ↑ Stamnes MA, Rutherford SL, Zuker CS. Cyclophilins: a new family of proteins involved in intracellular folding. Trends Cell Biol. 1992 Sep;2(9):272-6. PMID:14731520
  2. ↑ Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50. doi:, 10.1016/j.bbrc.2012.07.024. Epub 2012 Jul 16. PMID:22814107 doi:http://dx.doi.org/10.1016/j.bbrc.2012.07.024
  3. ↑ Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005 Jan;79(1):176-83. PMID:15596813 doi:http://dx.doi.org/10.1128/JVI.79.1.176-183.2005
  4. ↑ Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129 doi:10.1038/nchembio.342

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Michal Harel, Alexander Berchansky

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