Journal:Acta Cryst D:S2059798319006995
From Proteopedia
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The crystal structure of HuA21-scFv in complex with the extracellular domain (ECD) of HER2 was determined, which demonstrates that HuA21 binds almost the same epitope as chA21 and also provides insight into how substitutions in HuA21 improve the binding affinity compared with chA21. | The crystal structure of HuA21-scFv in complex with the extracellular domain (ECD) of HER2 was determined, which demonstrates that HuA21 binds almost the same epitope as chA21 and also provides insight into how substitutions in HuA21 improve the binding affinity compared with chA21. | ||
The binding epitopes of antibodies could contribute to understand their anti-tumor activities. Our HuA21-HER2 structure clearly shows that the epitope of HuA21 is located at the C-terminal part of subdomain I of HER2. This is a new epitope distinct from those described for Trastuzumab and Pertuzumab, which are located at subdomains IV and II, respectively. | The binding epitopes of antibodies could contribute to understand their anti-tumor activities. Our HuA21-HER2 structure clearly shows that the epitope of HuA21 is located at the C-terminal part of subdomain I of HER2. This is a new epitope distinct from those described for Trastuzumab and Pertuzumab, which are located at subdomains IV and II, respectively. | ||
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| + | <scene name='81/816443/Cv/3'>Overall structure of HuA21 scFv in complex with HER2 ECD</scene>. In ECD, the subdomains I, II, III and IV are colored red, green, blue and yellow, respectively. The light chain (V<sub>L</sub>) and heavy chain (V<sub>H</sub>) of HuA21 scFv are colored magenta and cyan, respectively. | ||
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 11:25, 23 May 2019
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
