This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

6iwy

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 06:36, 29 May 2019

Crystal structure of the flagellar cap protein FliD from Helicobacter pylori

Structural highlights

6iwy is a 1 chain structure with sequence from Campylobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	fliD, HP_0752 (Campylobacter pylori)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FLID_HELPY] Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.

Publication Abstract from PubMed

Helicobacter pylori is a pathogenic flagellated bacterium that infects the gastroduodenal mucosa and causes peptic ulcers in humans. FliD caps the distal end of the flagellar filament and is essential in filament growth. Moreover, FliD has been studied to diagnose and prevent H. pylori infection. Here, we report structure-based molecular studies of H. pylori FliD (hpFliD). A crystal structure of hpFliD at 2.6A resolution presents a four-domain (D2-D5) structure, where the D3 domain forms a central platform surrounded by the other three domains (D2, D4, and D5). hpFliD domains D2 and D3 structurally resemble those of FliD orthologs, whereas the D4 and D5 domains are exclusive to hpFliD. Moreover, our ELISA analysis using anti-H. pylori antibodies demonstrated that the hpFliD-specific D4 and D5 domains are highly antigenic compared to the D2 and D3 domains. Collectively, our structural and serological analyses underscore the structural role of hpFliD domains and provide a molecular basis for vaccine and diagnosis development.

Structural analysis of the flagellar capping protein FliD from Helicobacter pylori.,Cho SY, Song WS, Oh HB, Kim HU, Jung HS, Yoon SI Biochem Biophys Res Commun. 2019 Jun 18;514(1):98-104. doi:, 10.1016/j.bbrc.2019.04.065. Epub 2019 Apr 22. PMID:31023530^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cho SY, Song WS, Oh HB, Kim HU, Jung HS, Yoon SI. Structural analysis of the flagellar capping protein FliD from Helicobacter pylori. Biochem Biophys Res Commun. 2019 Jun 18;514(1):98-104. doi:, 10.1016/j.bbrc.2019.04.065. Epub 2019 Apr 22. PMID:31023530 doi:http://dx.doi.org/10.1016/j.bbrc.2019.04.065

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6iwy"

@@ Line 3: / Line 3: @@
 <StructureSection load='6iwy' size='340' side='right'caption='[[6iwy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6iwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IWY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6iwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IWY FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwy OCA], [http://pdbe.org/6iwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iwy RCSB], [http://www.ebi.ac.uk/pdbsum/6iwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwy ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliD, HP_0752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwy OCA], [http://pdbe.org/6iwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iwy RCSB], [http://www.ebi.ac.uk/pdbsum/6iwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwy ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Campylobacter pylori]]
 [[Category: Large Structures]]
 [[Category: Cho, S Y]]

6iwy

From Proteopedia

Revision as of 06:36, 29 May 2019

Crystal structure of the flagellar cap protein FliD from Helicobacter pylori

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox