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| | <StructureSection load='4wa5' size='340' side='right'caption='[[4wa5]], [[Resolution|resolution]] 1.95Å' scene=''> | | <StructureSection load='4wa5' size='340' side='right'caption='[[4wa5]], [[Resolution|resolution]] 1.95Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4wa5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/harbor_seal/massachusetts/1/2011(h3n8)) Influenza a virus (a/harbor seal/massachusetts/1/2011(h3n8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WA5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wa5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/harbor_seal/Massachusetts/1/2011(H3N8)) Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WA5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wa1|4wa1]], [[4wa2|4wa2]], [[4wa3|4wa3]], [[4wa4|4wa4]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa5 OCA], [https://pdbe.org/4wa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wa5 RCSB], [https://www.ebi.ac.uk/pdbsum/4wa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa5 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1136533 Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa5 OCA], [http://pdbe.org/4wa5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4wa5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa5 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] | + | [https://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Neuraminidase|Neuraminidase]] | + | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gubareva, L V]] | + | [[Category: Gubareva LV]] |
| - | [[Category: Stevens, J]] | + | [[Category: Stevens J]] |
| - | [[Category: Villanueva, J M]] | + | [[Category: Villanueva JM]] |
| - | [[Category: Yang, H]] | + | [[Category: Yang H]] |
| - | [[Category: Influenza virus]]
| + | |
| - | [[Category: Neuraminidase]]
| + | |
| - | [[Category: Seal]]
| + | |
| - | [[Category: Viral protein-inhibitor complex]]
| + | |
| Structural highlights
Function
I6NW33_9INFA Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
Publication Abstract from PubMed
In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference (Anthony et al. ; MBio 3: e00166-00112). Here we present a detailed structural and biochemical analysis of the surface antigens of this virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase, indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for cross-species transmission with these viruses, our results indicate that the A(H3N8) virus currently poses a low risk to humans. IMPORTANCE: Cross-species transmission of zoonotic influenza viruses increases public health concerns. Here we report a molecular and structural study of the major surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. Results improve our understanding of these viruses as they evolve and provide important information to aid ongoing risk assessment analyses, as these zoonotic influenza viruses continue to circulate and adapt to new hosts.
Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals.,Yang H, Nguyen HT, Carney PJ, Guo Z, Chang JC, Jones J, Davis CT, Villanueva JM, Gubareva LV, Stevens J J Virol. 2014 Dec 24. pii: JVI.02723-14. PMID:25540377[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Yang H, Nguyen HT, Carney PJ, Guo Z, Chang JC, Jones J, Davis CT, Villanueva JM, Gubareva LV, Stevens J. Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. J Virol. 2014 Dec 24. pii: JVI.02723-14. PMID:25540377 doi:http://dx.doi.org/10.1128/JVI.02723-14
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