4wgi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4wgi' size='340' side='right'caption='[[4wgi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4wgi' size='340' side='right'caption='[[4wgi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WGI FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WGI FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [https://pdbe.org/4wgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [https://www.ebi.ac.uk/pdbsum/4wgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wgi ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [http://pdbe.org/4wgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [http://www.ebi.ac.uk/pdbsum/4wgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wgi ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
+
[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 26: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Escherichia coli O157:H7]]
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Clifton, M C]]
+
[[Category: Clifton MC]]
-
[[Category: Fairman, J W]]
+
[[Category: D'Souza B]]
-
[[Category: Fang, C]]
+
[[Category: Fairman JW]]
-
[[Category: Fulroth, B]]
+
[[Category: Fang C]]
-
[[Category: Golub, T R]]
+
[[Category: Fulroth B]]
-
[[Category: Hubbard, B K]]
+
[[Category: Golub TR]]
-
[[Category: Kaushik, V]]
+
[[Category: Hubbard BK]]
-
[[Category: Leed, A]]
+
[[Category: Kaushik V]]
-
[[Category: McCarren, P]]
+
[[Category: Leed A]]
-
[[Category: Palmer, M]]
+
[[Category: McCarren P]]
-
[[Category: Serrano-Wu, M H]]
+
[[Category: Palmer M]]
-
[[Category: Souza, B D]]
+
[[Category: Serrano-Wu MH]]
-
[[Category: Wang, L]]
+
[[Category: Wang L]]
-
[[Category: Wang, Y]]
+
[[Category: Wang Y]]
-
[[Category: Wei, G]]
+
[[Category: Wei G]]
-
[[Category: Apoptosis-inhibitor complex]]
+
-
[[Category: Fusion protein]]
+
-
[[Category: Mbp]]
+
-
[[Category: Transport protein]]
+
-
[[Category: Transport protein-inhibitor complex]]
+

Revision as of 07:07, 7 April 2023

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

PDB ID 4wgi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wgi"
Personal tools