|
|
| Line 3: |
Line 3: |
| | <StructureSection load='4v4g' size='340' side='right'caption='[[4v4g]], [[Resolution|resolution]] 11.50Å' scene=''> | | <StructureSection load='4v4g' size='340' side='right'caption='[[4v4g]], [[Resolution|resolution]] 11.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4v4g]] is a 265 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voq 1voq], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vor 1vor], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vos 1vos], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vou 1vou], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vov 1vov], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vow 1vow], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vox 1vox], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voy 1voy], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voz 1voz] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vp0 1vp0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4G FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4v4g]] is a 50 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voq 1voq], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vor 1vor], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vos 1vos], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vou 1vou], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vov 1vov], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vow 1vow], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vox 1vox], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voy 1voy], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1voz 1voz] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vp0 1vp0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V4G FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4g OCA], [http://pdbe.org/4v4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v4g RCSB], [http://www.ebi.ac.uk/pdbsum/4v4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4g ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4g OCA], [https://pdbe.org/4v4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4g RCSB], [https://www.ebi.ac.uk/pdbsum/4v4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4g ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| Line 25: |
Line 25: |
| | [[Category: Escherichia coli]] | | [[Category: Escherichia coli]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cate, J H]] | + | [[Category: Cate JH]] |
| - | [[Category: Hau, C W]] | + | [[Category: Hau CW]] |
| - | [[Category: Schuwirth, B S]] | + | [[Category: Schuwirth BS]] |
| - | [[Category: Vila-Sanjurjo, A]] | + | [[Category: Vila-Sanjurjo A]] |
| - | [[Category: 30s ribosomal subunit]]
| + | |
| - | [[Category: Protein-protein complex]]
| + | |
| - | [[Category: Protein-rna complex]]
| + | |
| - | [[Category: Ribosome]]
| + | |
| - | [[Category: Rna-rna complex]]
| + | |
| Structural highlights
4v4g is a 50 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entries 1voq, 1vor, 1vos, 1vou, 1vov, 1vow, 1vox, 1voy, 1voz and 1vp0. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
During environmental stress, organisms limit protein synthesis by storing inactive ribosomes that are rapidly reactivated when conditions improve. Here we present structural and biochemical data showing that protein Y, an Escherichia coli stress protein, fills the tRNA- and mRNA-binding channel of the small ribosomal subunit to stabilize intact ribosomes. Protein Y inhibits translation initiation during cold shock but not at normal temperatures. Furthermore, protein Y competes with conserved translation initiation factors that, in bacteria, are required for ribosomal subunit dissociation. The mechanism used by protein Y to reduce translation initiation during stress and quickly release ribosomes for renewed translation initiation may therefore occur widely in nature.
Structural basis for the control of translation initiation during stress.,Vila-Sanjurjo A, Schuwirth BS, Hau CW, Cate JH Nat Struct Mol Biol. 2004 Nov;11(11):1054-9. Epub 2004 Oct 24. PMID:15502846[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Vila-Sanjurjo A, Schuwirth BS, Hau CW, Cate JH. Structural basis for the control of translation initiation during stress. Nat Struct Mol Biol. 2004 Nov;11(11):1054-9. Epub 2004 Oct 24. PMID:15502846 doi:http://dx.doi.org/10.1038/nsmb850
|
