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4wzg

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Revision as of 21:04, 12 April 2023

Structure of human ATG101

Structural highlights

4wzg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ATGA1_HUMAN Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.^[1] ^[2]

Publication Abstract from PubMed

ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fold. Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2. Moreover, we discuss a potential mode of dimerization with ATG13 as a fundamental aspect of ATG101 function.

The mammalian autophagy initiator complex contains two HORMA domain proteins.,Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergraber OH Autophagy. 2015 Aug 3:0. PMID:26236954^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy. 2009 Jul;5(5):649-62. Epub 2009 Jul 20. PMID:19287211
↑ Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy. 2009 Oct;5(7):973-9. Epub 2009 Oct 18. PMID:19597335
↑ Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergraber OH. The mammalian autophagy initiator complex contains two HORMA domain proteins. Autophagy. 2015 Aug 3:0. PMID:26236954 doi:http://dx.doi.org/10.1080/15548627.2015.1076605

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wzg"

Categories: Homo sapiens | Large Structures | Michel M | Weiergraeber OH

@@ Line 3: / Line 3: @@
 <StructureSection load='4wzg' size='340' side='right'caption='[[4wzg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WZG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WZG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG101, C12orf44, PP894 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzg OCA], [https://pdbe.org/4wzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wzg RCSB], [https://www.ebi.ac.uk/pdbsum/4wzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wzg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzg OCA], [http://pdbe.org/4wzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wzg RCSB], [http://www.ebi.ac.uk/pdbsum/4wzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wzg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>
+[https://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Michel, M]]
+[[Category: Michel M]]
-[[Category: Weiergraeber, O H]]
+[[Category: Weiergraeber OH]]
-[[Category: Atg13 binding]]
-[[Category: Autophagy]]
-[[Category: Horma domain]]
-[[Category: Protein binding]]
-[[Category: Ulk1 complex]]

4wzg

From Proteopedia

Revision as of 21:04, 12 April 2023

Structure of human ATG101

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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