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4uw3

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Revision as of 07:44, 29 March 2023

Human galectin-7 in complex with a galactose based dendron D1.

Structural highlights

4uw3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEG7_HUMAN

Publication Abstract from PubMed

Galectins are evolutionarily conserved and ubiquitously present animal lectins with a high affinity for beta-galactose containing oligosaccharides. To date, 15 mammalian galectins have been identified. Their involvement in cell-cell and cell-matrix interactions has highlighted their importance in signal transduction and other intracellular processes. Human Galectin-7 (hGal-7) is a 15kDa prototype galectin forms a dimer in solution and its involvement in the stimulation and development of tumour growth has been reported. Previously we had reported the crystal structure of hGal-7 and its complex with galactose and lactose which have provided insight into its molecular recognition and detailed interactions. Here, we present the newly obtained high resolution structural data on carbohydrate based dendrons in complex with hGal-7. Our crystallographic data reveal how multivalent ligands interact with and form cross-links with these galectin molecules. Understanding how these dendrimeric compounds interact with hGal-7 would help the design of new tools to investigate the recognition of carbohydrates by lectins. This article is protected by copyright. All rights reserved.

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.,Ramaswamy S, Haj Sleiman M, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR FEBS J. 2014 Nov 4. doi: 10.1111/febs.13140. PMID:25367374^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ramaswamy S, Haj Sleiman M, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR. Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7. FEBS J. 2014 Nov 4. doi: 10.1111/febs.13140. PMID:25367374 doi:http://dx.doi.org/10.1111/febs.13140

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4uw3"

@@ Line 3: / Line 3: @@
 <StructureSection load='4uw3' size='340' side='right'caption='[[4uw3]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4uw3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UW3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4uw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UW3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=50G:DENDRON-D1'>50G</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=50G:DENDRON-D1'>50G</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uw4|4uw4]], [[4uw5|4uw5]], [[4uw6|4uw6]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw3 OCA], [https://pdbe.org/4uw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4uw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw3 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw3 OCA], [http://pdbe.org/4uw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw3 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 20: @@
 ==See Also==
-*[[Galectin|Galectin]]
+*[[Galectin 3D structures|Galectin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Acharya, K R]]
+[[Category: Acharya KR]]
-[[Category: Arbez-Gindre, C]]
+[[Category: Arbez-Gindre C]]
-[[Category: Calogeropoulou, T]]
+[[Category: Calogeropoulou T]]
-[[Category: Masuyer, G]]
+[[Category: Masuyer G]]
-[[Category: Micha-Screttas, M]]
+[[Category: Micha-Screttas M]]
-[[Category: Ramaswamy, S]]
+[[Category: Ramaswamy S]]
-[[Category: Sleiman, M H]]
+[[Category: Sleiman MH]]
-[[Category: Steele, B R]]
+[[Category: Steele BR]]
-[[Category: Carbohydrate binding]]
-[[Category: Dendrimer]]
-[[Category: Galectin-7]]
-[[Category: Lectin]]
-[[Category: Multivalency]]
-[[Category: Sugar binding protein]]

4uw3

From Proteopedia

Revision as of 07:44, 29 March 2023

Human galectin-7 in complex with a galactose based dendron D1.

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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